- ≥99% HPLC purity
- Lot-matched certificate of analysis
- Ships next business day, tracked
Kisspeptin-10 Troches (Sublingual)
Sublingual troches of the KISS1R decapeptide agonist, 500 mcg per unit
- FormSublingual troche in a slowly dissolving compounding base
- Research areasGnRH pulse generation, HPG-axis regulation, transmucosal peptide delivery, formulation stability
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
These sublingual troches supply kisspeptin-10, the ten-residue C-terminal fragment of the KISS1 gene product, in a slowly dissolving base at 500 micrograms per unit with thirty units to the pack. The peptide is the same amidated decapeptide we supply as lyophilized powder — Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 — whose C-terminal Arg-Phe-amide motif is essential for activity at KISS1R, the Gq-coupled receptor originally catalogued as GPR54.
Kisspeptin signalling sits at the top of the reproductive endocrine cascade. Kisspeptin neurons in the hypothalamus drive GnRH release, which in turn governs LH and FSH secretion, and loss-of-function mutations in KISS1R were the genetic finding that established the pathway's necessity for puberty. That upstream position is why the peptide appears in neuroendocrine research rather than in receptor-level work alone.
Specifications
Supply & purity
- Form
- Sublingual troche in a slowly dissolving compounding base
Additional detail
- Peptide content
- 500 mcg kisspeptin-10 per troche
- Available size
- 30 troches per pack
- Active component
- Kisspeptin-10, C-terminal decapeptide fragment of kisspeptin-54 (metastin)
- Amino acid sequence (active)
- Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
- CAS number (active)
- 374675-21-5
- Molecular formula (active)
- C63H83N17O14
- Molecular weight (active)
- 1302.47 g/mol
- Receptor target
- KISS1R (GPR54), a Gq/11-coupled class A GPCR
- Peptide purity
- ≥99% by HPLC before compounding; lot-matched COA available
- Delivery route studied
- Sublingual and buccal mucosal absorption
- Research areas
- GnRH pulse generation, HPG-axis regulation, transmucosal peptide delivery, formulation stability
- Storage
- Cool, dry and dark in the closed pack; refrigeration extends shelf stability
Questions about Kisspeptin-10 Troches (Sublingual)
How does this differ from the kisspeptin-10 vial?
The peptide is identical; only the presentation changes. The vial is lyophilized powder that a laboratory reconstitutes to any concentration, while each troche is a fixed 500 mcg unit in a dissolving base intended for transmucosal delivery research.
How does it compare with the nasal spray format?
Both are transmucosal routes but they use different epithelia. Nasal mucosa is thin and highly vascular with a short residence time; sublingual mucosa offers longer contact but a smaller absorptive area. Comparing the two with the same peptide lot is a standard route-comparison design.
What documentation is provided?
The peptide used in manufacture is released at ≥99% purity by reversed-phase HPLC with mass-spectrometric identity confirmation, and a lot-matched certificate of analysis is available. Retain it with your records so results can be traced to the specific peptide lot.
How should the troches be stored?
Keep them sealed, cool, dry and away from light. Heat softens the base and atmospheric moisture is absorbed by it, both of which degrade the units physically and accelerate peptide breakdown. Refrigerated storage in a closed container extends the usable window.
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