- ≥99% by HPLC; lot-matched COA
- Lot-matched certificate of analysis
- Ships next business day, tracked
Triptorelin
Long-acting GnRH superagonist with a D-Trp6 substitution
- FormLyophilized white to off-white powder, sealed glass vial
- Mol. weight1311.45 g/mol
- Research areasGnRH receptor desensitisation, reversible HPG-axis suppression models, superagonist structure–activity work
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Triptorelin is a synthetic decapeptide analogue of gonadotropin-releasing hormone in which the glycine at position 6 is replaced by D-tryptophan. That single substitution is the whole design: it blocks enzymatic cleavage at the Gly6-Leu7 bond, the primary degradation route for native GnRH, and simultaneously stabilises a conformation with higher receptor affinity. The result is a molecule that is both far more potent and far longer-lived than the hormone it is modelled on — the definition of a GnRH superagonist.
Its pharmacology is deliberately biphasic, and that is what makes it experimentally interesting. Initial exposure produces a transient surge in luteinising hormone and follicle-stimulating hormone as gonadotrophs are strongly stimulated. Sustained exposure then does the opposite: GnRH receptors internalise, uncouple from their signalling machinery and downregulate, and gonadotropin output falls to well below baseline. Because native GnRH clears too quickly to hold receptors occupied, this paradoxical suppression is essentially inaccessible without an analogue, which is why triptorelin became a standard laboratory tool for producing reversible axis suppression in model systems.
Specifications
Identity
- CAS number
- 57773-63-4
- Molecular formula
- C64H82N18O13
- Molecular weight
- 1311.45 g/mol
- Amino acid sequence
- pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
- Peptide class
- Linear amidated decapeptide; GnRH superagonist analogue
Supply & purity
- Form
- Lyophilized white to off-white powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA
- Solubility
- Soluble in water and bacteriostatic water; dilute acetic acid or a trace of DMSO aids stubborn lots
Handling & storage
- Storage (lyophilized)
- −20 °C, desiccated and protected from light
- Storage (reconstituted)
- 2–8 °C for short-term use; aliquot and freeze for longer holds
Additional detail
- Available size
- 2 mg
- Receptor target
- GnRH receptor (GnRHR) on pituitary gonadotrophs, Gq/11-coupled
- Research areas
- GnRH receptor desensitisation, reversible HPG-axis suppression models, superagonist structure–activity work
Questions about Triptorelin
What makes triptorelin a superagonist rather than just an agonist?
The D-tryptophan at position 6 blocks the enzymatic cleavage that clears native GnRH within minutes and stabilises a higher-affinity conformation. The combination gives greatly increased potency and duration relative to the parent hormone, which is what the term superagonist describes.
Why would an agonist suppress the axis it stimulates?
Pituitary gonadotrophs respond to pulsatile signalling. A long-lived agonist keeps receptors continuously occupied, which triggers internalisation, uncoupling and downregulation. After an initial surge, gonadotropin output falls below baseline — a paradoxical effect that native, fast-clearing GnRH cannot produce.
How does it compare with gonadorelin?
They act on the same pituitary receptor but on completely different timescales. Gonadorelin is native GnRH and clears in minutes, making it the tool for pulsatile stimulation. Triptorelin persists, making it the tool for studying receptor desensitisation. The pair is a natural matched comparison.
Is a certificate of analysis available?
Yes. Each lot is analysed by reverse-phase HPLC for purity of ≥99% and confirmed by mass spectrometry, with a lot-matched COA supplied on request. The vial's batch number matches the document so measurements remain traceable to a specific analysis.
Why is only a 2 mg vial offered?
Triptorelin is potent enough that receptor-level and cell-culture work typically consumes very little material, so a 2 mg vial covers most study designs comfortably. Keeping to a single size also means a full experimental series can usually run on one lot, removing batch variability as a confounder.
Does it need special protection from light?
More than most peptides of this size, yes. Triptorelin carries two tryptophan residues, both oxidation-sensitive, so keep vials and solutions shielded from light and minimise headspace air exposure. Amber tubes or foil-wrapped aliquots are worth the small extra effort.
Can triptorelin be used for anything other than laboratory research?
No. It is supplied strictly as a research chemical for in vitro and laboratory investigation. It is not a medicine, supplement or veterinary product, we provide no dosing or administration guidance of any kind, and purchasers confirm they are qualified to handle research materials.
Related
