- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
KPV
Lys-Pro-Val tripeptide from the alpha-MSH C-terminus, lyophilized vials
- FormLyophilized powder, sealed glass vial with crimped stopper
- Mol. weight342.43 g/mol
- Research areasInflammatory signalling, NF-kappa B pathway, intestinal and dermal inflammation models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
KPV is a tripeptide of lysine, proline and valine that reproduces the C-terminal three residues of alpha-melanocyte-stimulating hormone. It is one of the shortest sequences in active inflammation research, and that brevity is the point: the fragment retains the anti-inflammatory character attributed to the parent hormone in cell work while carrying none of the melanocortin receptor activity responsible for alpha-MSH pigmentation effects.
The peptide is produced by solid-phase synthesis, purified by reversed-phase HPLC to at least 99% and supplied as a lyophilized powder in a sealed glass vial in 5 mg and 10 mg sizes. Because the molecule weighs only 342 g/mol, a single milligram represents a large molar quantity relative to longer peptides, so these vial sizes cover a considerable amount of plate-based or animal work.
Specifications
Identity
- CAS number
- 67727-97-3
- Molecular formula
- C16H30N4O4
- Molecular weight
- 342.43 g/mol
- Amino acid sequence
- Lys-Pro-Val
- Chain length
- 3 amino acids (tripeptide)
- Peptide class
- Melanocortin-derived tripeptide; C-terminal fragment of alpha-MSH (11–13)
Supply & purity
- Form
- Lyophilized powder, sealed glass vial with crimped stopper
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 5 mg, 10 mg
- Solubility
- Freely soluble in bacteriostatic or sterile water
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light, used within the study window
Additional detail
- Research areas
- Inflammatory signalling, NF-kappa B pathway, intestinal and dermal inflammation models
Questions about KPV
What is KPV?
KPV is a synthetic tripeptide made of lysine, proline and valine that corresponds to the last three residues of alpha-melanocyte-stimulating hormone. It is supplied as a lyophilized research powder and is studied mainly in models of inflammatory signalling and intestinal epithelial function.
How does KPV differ from alpha-MSH?
Alpha-MSH is a thirteen-residue hormone that acts at melanocortin receptors and influences pigmentation as well as inflammation. KPV is only its final three residues. Research reports retention of the anti-inflammatory character without the receptor-mediated pigmentation activity of the full sequence.
Is a certificate of analysis available?
Yes. Every lot is analysed by reversed-phase HPLC to at least 99% purity with mass confirmation of the expected 342.43 g/mol mass, and a certificate matched to the lot number on your vial label is available on request before or after ordering.
Which size should I order?
Both the 5 mg and 10 mg vials go a long way because the peptide is so light: at 342 g/mol, a milligram is a far larger molar quantity than a milligram of a thirty-residue peptide. Choose the 5 mg for pilot work and 10 mg for extended series.
What is KPV usually dissolved in?
Laboratories most commonly reconstitute with bacteriostatic or sterile water, in which the tripeptide dissolves readily to give a clear solution. Buffered systems are used where an assay requires controlled pH. The choice of solvent belongs to the study design and is made by the researcher.
Can KPV be used in humans?
No. This is a research chemical intended for in-vitro and laboratory investigation by qualified personnel only. It is not approved as a drug or supplement anywhere, and it is supplied without dosing, administration or protocol guidance of any kind.
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