- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Nonapeptide-1 (Melanostatine-5)
Nine-residue amidated MC1R-antagonist peptide for melanogenesis models
- FormLyophilized powder, sealed glass vial
- Mol. weight1206.50 g/mol
- Research areasAlpha-MSH competition, MC1R signaling, tyrosinase regulation and melanogenesis
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Nonapeptide-1 is a synthetic nine-residue amidated peptide also known as Melanostatine-5. Its sequence—Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2—contains two D-amino acids that stabilize the conformation and distinguish it from an ordinary all-L peptide. The internal Phe-Arg-Trp run echoes part of the His-Phe-Arg-Trp message motif shared by melanocortin ligands, although the histidine of that motif is not present in this analogue. It was identified through melanocortin peptide-library work as an antagonist candidate at melanocortin-1 receptor (MC1R).
Specifications
Identity
- CAS number
- 158563-45-2
- Molecular formula
- C61H87N15O9S
- Molecular weight
- 1206.50 g/mol
- Amino acid sequence
- Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2
- Chain length
- 9 residues, C-terminally amidated
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
Additional detail
- Available size
- 200 mg
- Also known as
- Melanostatine-5, Melanostatine 5, Nonapeptide-1
- Research target
- Melanocortin-1 receptor (MC1R) antagonist models
- Research areas
- Alpha-MSH competition, MC1R signaling, tyrosinase regulation and melanogenesis
- Storage
- −20 °C lyophilized; protect powder and solutions from light
Questions about Nonapeptide-1 (Melanostatine-5)
What is Nonapeptide-1?
It is a synthetic nine-residue peptide, also called Melanostatine-5, developed as an antagonist candidate for MC1R signaling. The sequence includes D-phenylalanine and D-tryptophan and ends in a C-terminal amide.
How does Nonapeptide-1 differ from Decapeptide-12?
Nonapeptide-1 is studied primarily at the receptor-signaling level through MC1R and alpha-MSH competition. Decapeptide-12 is studied more directly as a tyrosinase inhibitor. They address different steps in melanogenesis and are useful comparison reagents, not duplicates.
Why are D-amino acids important in the sequence?
D-Phe3 and D-Trp5 alter the peptide's three-dimensional geometry and protease susceptibility. A material made with the corresponding L residues would not be the same research compound even if the residue names looked similar on a label.
What purity documentation is available?
Each lot is analyzed by reversed-phase HPLC to at least 99% purity and is accompanied by a lot-matched certificate of analysis on request. Mass confirmation should match the amidated peptide form.
How should Nonapeptide-1 be stored?
Store the sealed powder at −20 °C, protected from moisture and light. Keep prepared solutions refrigerated for a defined study window and use aliquots when work extends across multiple sessions.
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