Palmitoyl Tetrapeptide-7 (Pal-GQPR)

Palmitoyl Tetrapeptide-7 is the N-palmitoylated form of Gly-Gln-Pro-Arg, abbreviated Pal-GQPR. The GQPR sequence is associated with an immunoglobulin G fragment, while the attached sixteen-carbon chain raises lipophilicity and changes how the peptide partitions into membranes, emulsions and other lipid-rich systems. Free GQPR is also catalogued as rigin, and it shares its C-terminal Pro-Arg motif with tuftsin (Thr-Lys-Pro-Arg), another short immunoglobulin-derived sequence — a relationship worth noting because it places the peptide outside the true matrikines, which are fragments of extracellular-matrix proteins rather than of an antibody.

This ingredient is often encountered as one half of Matrixyl 3000-type formulations alongside Palmitoyl Tripeptide-1. A standalone vial lets laboratories study Pal-GQPR independently, quantify it separately and run single-agent controls before interpreting a two-peptide blend. Published work is weighted toward formulation, fibroblast, extracellular-matrix and cytokine-marker models, with independent evidence more limited than branded mixture claims may suggest. Acylation adds roughly 238 Da of purely hydrophobic mass to the tetrapeptide, so equal-weight comparisons against the unmodified sequence deliver unequal numbers of molecules and matched-molarity designs are the meaningful ones.

The 200 mg vial contains lyophilized Pal-GQPR, CAS 221227-05-0, formula C34H62N8O7 and molecular weight 694.91 g/mol. It is HPLC tested with a lot-matched COA available and is supplied strictly as a laboratory research material, not as a finished cosmetic or drug.

Palmitoyl Tetrapeptide-7 (Pal-GQPR) ships as a lyophilized powder, so nothing on this page can state a concentration: the figure you work with is the one you create when you add diluent. Put the vial mass and the volume you intend to use into the peptide reconstitution calculator and it returns mg/mL, mcg/mL and the mass sitting at each mark on a U-100 syringe.

If the protocol asks for a molar concentration, the molar concentration calculator converts between 694.91 g/mol, the mass you weigh out and the volume you dissolve it in.