Palmitoyl Tetrapeptide-7 (Pal-GQPR)

Palmitoyl Tetrapeptide-7 is the N-palmitoylated form of Gly-Gln-Pro-Arg, abbreviated Pal-GQPR. The GQPR sequence is associated with an immunoglobulin G fragment, while the attached sixteen-carbon chain raises lipophilicity and changes how the peptide partitions into membranes, emulsions and other lipid-rich systems. Free GQPR is also catalogued as rigin, and it shares its C-terminal Pro-Arg motif with tuftsin (Thr-Lys-Pro-Arg), another short immunoglobulin-derived sequence — a relationship worth noting because it places the peptide outside the true matrikines, which are fragments of extracellular-matrix proteins rather than of an antibody.

This ingredient is often encountered as one half of Matrixyl 3000-type formulations alongside Palmitoyl Tripeptide-1. A standalone vial lets laboratories study Pal-GQPR independently, quantify it separately and run single-agent controls before interpreting a two-peptide blend. Published work is weighted toward formulation, fibroblast, extracellular-matrix and cytokine-marker models, with independent evidence more limited than branded mixture claims may suggest. Acylation adds roughly 238 Da of purely hydrophobic mass to the tetrapeptide, so equal-weight comparisons against the unmodified sequence deliver unequal numbers of molecules and matched-molarity designs are the meaningful ones.

The 200 mg vial contains lyophilized Pal-GQPR, CAS 221227-05-0, formula C34H62N8O7 and molecular weight 694.91 g/mol. It is HPLC tested with a lot-matched COA available and is supplied strictly as a laboratory research material, not as a finished cosmetic or drug.