- ≥99% by HPLC with mass-spectrometric identity check; COA per lot
- Lot-matched certificate of analysis
- Ships next business day, tracked
SNAP-8 (Acetyl Octapeptide-3)
Acetyl octapeptide-3 — SNAP-25 mimetic studied in SNARE assembly research
- FormWhite lyophilized powder in a sealed glass vial
- Mol. weight1075.16 g/mol
- Research areasSNARE complex assembly, catecholamine release, expression-line models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
SNAP-8, sold under the INCI name acetyl octapeptide-3, is an eight-residue, N-acetylated and C-amidated peptide designed as a mimetic of the N-terminal region of SNAP-25. SNAP-25 is one of the three proteins that form the SNARE complex, the machinery that docks and fuses neurotransmitter vesicles with the presynaptic membrane. By presenting a competing fragment of that sequence, SNAP-8 is studied as an extracellular interference agent in SNARE assembly — a different point of attack from botulinum neurotoxin, which cleaves SNAP-25 inside the cell.
Structurally it is an extended relative of acetyl hexapeptide-8 (Argireline): the same Glu-Glu-Met-Gln-Arg-Arg core with two additional residues, alanine and aspartate, at the C-terminal end. Cosmetic-science literature commonly frames the extension as a way to improve affinity for the SNARE interaction site, and the two peptides are routinely compared in the same experimental series.
MyPeptide supplies SNAP-8 as a lyophilized powder in 10 mg and 50 mg vials, third-party tested to ≥99% by HPLC with a lot-matched certificate of analysis, shipped from the United States. It is offered for laboratory research only.
Specifications
Identity
- CAS number
- 868844-74-0
- Molecular formula
- C41H70N16O16S
- Molecular weight
- 1075.16 g/mol
- Amino acid sequence
- Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
- Peptide class
- Cosmetic signal peptide; SNAP-25 N-terminal mimetic
Supply & purity
- Form
- White lyophilized powder in a sealed glass vial
- Purity
- ≥99% by HPLC with mass-spectrometric identity check; COA per lot
- Available sizes
- 10 mg, 50 mg
- Solubility
- Water, bacteriostatic water; soluble in aqueous cosmetic vehicles
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed, protected from light and moisture
Additional detail
- INCI name
- Acetyl Octapeptide-3
- Research areas
- SNARE complex assembly, catecholamine release, expression-line models
- Storage (in solution)
- 2–8 °C in a defined buffer; prepare fresh where possible
Questions about SNAP-8 (Acetyl Octapeptide-3)
What is SNAP-8?
SNAP-8 is acetyl octapeptide-3, an eight-amino-acid acetylated peptide modelled on the N-terminal region of the SNAP-25 protein. It is used in laboratory research as a competing fragment at the SNARE assembly interface and appears widely in cosmetic-ingredient and vesicle-fusion literature.
How does SNAP-8 relate to Argireline?
Both are built on the same Glu-Glu-Met-Gln-Arg-Arg core. SNAP-8 extends it by two residues, alanine and aspartate, giving an octapeptide instead of a hexapeptide. The extension is described in the ingredient literature as favouring interaction with the SNARE site, and the two are commonly tested side by side.
Is this lot third-party tested, and can I see the COA?
Yes. Every production lot is analysed by an independent laboratory for identity and purity — HPLC with mass-spectrometric confirmation — and the lot-matched certificate of analysis is available on request before purchase. The COA states the lot number, assay result and test date so it can be filed with your experimental records.
Is SNAP-8 water-soluble?
Yes. The peptide dissolves readily in water and in bacteriostatic water, and is generally compatible with aqueous research vehicles. Solubility makes it convenient for buffer-based assays, though the working pH and any co-solvents should be recorded because they affect stability of the dissolved peptide.
Which sizes are stocked?
SNAP-8 is offered in a 10 mg vial for small assay work and a 50 mg vial for larger formulation or repeated-experiment programmes. Both contain the peptide alone as a lyophilized cake, with no diluent or preservative included.
How should SNAP-8 be stored?
Keep the unopened lyophilized vial at −20 °C, sealed against light and moisture. Solutions should be kept at 2–8 °C in a defined buffer and used within a short window; the methionine residue makes long aqueous storage and repeated freeze–thaw undesirable.
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