- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Syn-AKE (Dipeptide Diaminobutyroyl Benzylamide Diacetate)
Modified dipeptide diacetate studied in nicotinic-receptor model systems
- FormLyophilized diacetate salt, sealed glass vial
- Mol. weight495.57 g/mol as the diacetate
- Research areasNicotinic acetylcholine receptor models, contraction-frequency assays and cosmetic-peptide formulation
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
The compound was designed as a small analog inspired by waglerin-1 research. Laboratory and formulation studies discuss reversible antagonism at nicotinic acetylcholine receptor models and changes in contraction frequency in innervated cell systems. Evidence is limited, and results from a 22-residue venom peptide cannot be assumed for this much smaller analog without direct measurement.
The diacetate salt form has practical consequences. Two acetate counterions are part of the supplied mass, so a gravimetric weighing corresponds to less free base than the same figure would for an unsalted peptide, and quantitative work should state which form a concentration refers to. The benzylamide C-terminus is uncharged and comparatively lipophilic, which together with the basic diaminobutyric-acid side chain gives the molecule mixed solubility behaviour that is worth establishing empirically in each vehicle rather than assumed from the peptide-like formula.
Specifications
Identity
- CAS number
- 823202-99-9
- Molecular formula
- C23H37N5O7, including two acetate molecules
- Molecular weight
- 495.57 g/mol as the diacetate
Supply & purity
- Form
- Lyophilized diacetate salt, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
Additional detail
- Available size
- 200 mg
- Structural notation
- beta-Ala-Pro-Dab-NH-benzyl · 2 acetate
- INCI name
- Dipeptide Diaminobutyroyl Benzylamide Diacetate
- Also known as
- Syn-AKE, Syn-Ake acetate, snake peptide diacetate
- Compound class
- Modified peptide-like diaminobutyroyl benzylamide salt
- Research areas
- Nicotinic acetylcholine receptor models, contraction-frequency assays and cosmetic-peptide formulation
- Storage
- −20 °C lyophilized, protected from light and moisture
Questions about Syn-AKE (Dipeptide Diaminobutyroyl Benzylamide Diacetate)
What is the precise chemical name for Syn-AKE?
The precise INCI identity is Dipeptide Diaminobutyroyl Benzylamide Diacetate. The supplied form contains a beta-Ala-Pro-Dab-NH-benzyl core with two acetate counterions and is registered under CAS 823202-99-9.
Is Syn-AKE the same as waglerin-1?
No. Waglerin-1 is a 22-residue venom peptide. Syn-AKE is a much smaller synthetic analog inspired by one aspect of waglerin research. They differ in size, sequence, selectivity evidence and analytical identity.
How does it differ from Vialox?
Vialox is the defined pentapeptide Gly-Pro-Arg-Pro-Ala. Syn-AKE is a modified diaminobutyroyl benzylamide diacetate. Both appear in contraction-associated research, but they are separate molecules with different proposed receptor interactions.
What purity documentation is available?
The supplied diacetate material is released at ≥99% purity by HPLC with a lot-matched certificate of analysis. Molecular-weight calculations should use the salt form shown on that documentation.
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