- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Syn-Coll (Palmitoyl Tripeptide-5)
Pal-KVK signal tripeptide for TGF-beta and matrix-model research
- FormLyophilized amphiphilic peptide powder, sealed glass vial
- Mol. weight611.90 g/mol as the free peptide
- Research areasTGF-beta signaling, fibroblast matrix output, collagen-associated markers and matrix-metalloproteinase models
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Syn-Coll is the common trade-style name for Palmitoyl Tripeptide-5, a lipidated Lys-Val-Lys sequence written Pal-KVK. Its N-terminal C16 chain gives the peptide an amphiphilic character, while the basic lysine residues distinguish its charge and formulation behavior from other palmitoylated matrikines such as Pal-GHK and Pal-GQPR.
The compound was designed for extracellular-matrix research around transforming growth factor beta (TGF-beta) signaling and collagen-associated readouts. Studies and supplier dossiers have examined fibroblast matrix output, latent TGF-beta activation and matrix-metalloproteinase markers, but much of the evidence is formulation-specific or commercial. Direct analytical and single-agent controls are necessary before assigning an effect to Pal-KVK.
This 200 mg research vial contains Palmitoyl Tripeptide-5, formula C33H65N5O5 and molecular weight 611.90 g/mol. The peptide is HPLC tested with a lot-matched COA available. It is not a finished cosmetic and is supplied only for laboratory formulation and cell-model work.
Comparison with other lipidated matrikines is informative but should be handled carefully. Matrixyl is palmitoyl pentapeptide-4 built on the KTTKS sequence, Pal-GHK carries the copper-binding GHK motif, and Pal-GQPR is a distinct tetrapeptide; sharing a C16 chain does not imply a shared mechanism. The lysine-rich Pal-KVK core also behaves differently in anionic systems, so vehicle compatibility established for one palmitoylated peptide should be re-established here rather than carried across.
Specifications
Identity
- CAS number
- 623172-56-5
- Molecular formula
- C33H65N5O5
- Molecular weight
- 611.90 g/mol as the free peptide
- Peptide class
- Lipidated signal tripeptide
Supply & purity
- Form
- Lyophilized amphiphilic peptide powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Solubility
- Low water solubility; validate a co-solvent or surfactant vehicle
Additional detail
- Available size
- 200 mg
- Sequence
- Palmitoyl-Lys-Val-Lys-OH (Pal-KVK)
- Also known as
- Syn-Coll, Syn-Coll peptide, Palmitoyl Tripeptide-5
- Research areas
- TGF-beta signaling, fibroblast matrix output, collagen-associated markers and matrix-metalloproteinase models
- Storage
- −20 °C lyophilized, protected from light and moisture
Questions about Syn-Coll (Palmitoyl Tripeptide-5)
What is the sequence of Syn-Coll?
The defined peptide is Palmitoyl-Lys-Val-Lys-OH, abbreviated Pal-KVK. It is cataloged as Palmitoyl Tripeptide-5 and has a free-peptide molecular weight of 611.90 g/mol.
Is Syn-Coll the same as Matrixyl?
No. Matrixyl is most commonly associated with Palmitoyl Pentapeptide-4, sequence Pal-KTTKS. Syn-Coll is Palmitoyl Tripeptide-5, sequence Pal-KVK. They are distinct compounds and need separate pages and controls.
Is it the same as Palmitoyl Tripeptide-1?
No. Palmitoyl Tripeptide-1 is Pal-GHK, while this product is Pal-KVK. They share a lipidation strategy but not the peptide sequence or research rationale.
Why is a co-solvent sometimes needed?
The C16 palmitoyl group makes the molecule poorly soluble in plain water and prone to surface adsorption or self-association. A documented co-solvent or surfactant can improve reproducibility, provided the same vehicle is used in controls.
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