- ≥99% by HPLC; lot-matched COA available
- Lot-matched certificate of analysis
- Ships next business day, tracked
Tripeptide-29 (Gly-Pro-Hyp)
Gly-Pro-Hyp collagen tripeptide for matrix, stability and enzyme models
- FormLyophilized powder, sealed glass vial
- Mol. weight285.30 g/mol
- Research areasCollagen hydrolysate composition, peptide transport, fibroblast models, glycation, oxidative stress and DPP-IV assays
Supplied for laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
Overview
Tripeptide-29 is glycyl-L-prolyl-L-hydroxyproline, abbreviated Gly-Pro-Hyp. The motif recurs throughout collagen and is commonly detected among the small peptides produced by collagen hydrolysis. Hydroxyproline distinguishes it from Gly-Pro-Pro and contributes the hydroxyl group central to many collagen-structure and peptide-transport studies.
Research applications span collagen-model stability, uptake and metabolism of collagen-derived peptides, fibroblast responses to hydrolysate fractions, glycation/oxidative-stress assays and in-vitro enzyme work involving DPP-IV. A single purified tripeptide helps determine whether an observation attributed to a complex collagen hydrolysate can actually be reproduced by Gly-Pro-Hyp alone.
The product is supplied as a 200 mg lyophilized vial, CAS 2239-67-0, formula C12H19N3O5 and molecular weight 285.30 g/mol. It is HPLC tested with lot-matched documentation and is intended only for analytical, biochemical and cell-model research—not as a food, supplement, cosmetic or drug.
Identity precision matters for this reagent. Gly-Pro-Hyp is frequently discussed alongside Pro-Hyp and Hyp-Gly, which are different molecules that appear in the same collagen-hydrolysate literature, and hydroxyproline itself is a diastereomeric centre, so catalogue entries should specify 4-hydroxy-L-proline rather than 'Hyp' alone. Supplying the tripeptide as a single purified compound with documented HPLC purity is what allows it to serve as an analytical reference against which mixed hydrolysate fractions can be quantified.
Specifications
Identity
- CAS number
- 2239-67-0
- Molecular formula
- C12H19N3O5
- Molecular weight
- 285.30 g/mol
- Amino acid sequence
- Gly-Pro-Hyp (glycyl-prolyl-hydroxyproline)
- Chain length
- 3 residues
- Peptide class
- Collagen-derived imino-acid-rich tripeptide
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Solubility
- Water-soluble
Additional detail
- Available size
- 200 mg
- Also known as
- Gly-Pro-Hyp, GPH, collagen tripeptide, Tripeptide-29
- Research areas
- Collagen hydrolysate composition, peptide transport, fibroblast models, glycation, oxidative stress and DPP-IV assays
- Storage
- −20 °C lyophilized; keep sealed and dry
Questions about Tripeptide-29 (Gly-Pro-Hyp)
What is Tripeptide-29?
Tripeptide-29 is the defined three-residue collagen peptide Gly-Pro-Hyp, or glycyl-prolyl-hydroxyproline. It is one of the recurring motifs and digestion products associated with collagen.
Is Tripeptide-29 the same as collagen hydrolysate?
No. A collagen hydrolysate contains many peptides of different lengths and sequences. This vial contains one purified tripeptide, making it useful as an analytical standard or single-agent control.
Why is hydroxyproline important?
Hydroxyproline is characteristic of collagen and affects peptide conformation, enzyme susceptibility and analytical detection. Measuring total hydroxyproline alone, however, cannot prove that intact Gly-Pro-Hyp is present.
What purity documentation is available?
The material is released at ≥99% purity by HPLC with a lot-matched certificate of analysis. Quantitative protocols should account for any counterion or water content shown on the lot documentation.
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