- ≥99% by HPLC
- Lot-matched certificate of analysis
- Ships next business day, tracked
Vesugen
Lys-Glu-Asp (KED) tripeptide bioregulator used in vascular research models
- FormLyophilized powder in a sealed glass vial
- Mol. weight390.39 g/mol
- Research areasEndothelial cell models, vascular tissue, gene expression, vascular ageing
Overview
Vesugen is a synthetic tripeptide composed of L-lysine, L-glutamic acid, and L-aspartic acid (Lys-Glu-Asp, or KED). It is the vascular member of the Khavinson short-peptide bioregulator series, developed from earlier preparations made from vessel-wall tissue and then reduced to a defined three-residue sequence that can be synthesised and analysed precisely.
Structurally, KED extends the Vilon dipeptide by a single aspartate residue, which gives it a second free carboxylate and a more strongly anionic character at physiological pH. That difference is part of why the peptide is interesting to structural chemists: the series offers a set of closely related molecules that differ by one residue at a time, making it possible to test how small changes in sequence alter reported binding preferences for DNA and for cell-surface targets.
Laboratory work with Vesugen concentrates on endothelial cell cultures, isolated vessel preparations, and rodent models where markers of vascular tone, endothelial gene expression, and age-related changes in vessel wall structure are measured. Our material ships as a 20 mg lyophilized vial produced by solid-phase peptide synthesis and purified by HPLC to a ≥99% specification, with a lot-matched certificate of analysis available. It is supplied for laboratory research only.
Specifications
Identity
- CAS number
- 204271-66-9
- Molecular formula
- C15H26N4O8
- Molecular weight
- 390.39 g/mol
- Amino acid sequence
- Lys-Glu-Asp (KED), linear tripeptide with free N- and C-termini
- Peptide class
- Khavinson short-peptide bioregulator (tripeptide)
Supply & purity
- Form
- Lyophilized powder in a sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Available sizes
- 20 mg
- Solubility
- Bacteriostatic or sterile water; readily soluble in aqueous buffers
Handling & storage
- Storage (lyophilized)
- −20 °C, sealed and protected from light and moisture
- Storage (reconstituted)
- 2–8 °C, protected from light; use within the study window
Additional detail
- Tissue association
- Vascular and vessel-wall peptide preparations
- Research areas
- Endothelial cell models, vascular tissue, gene expression, vascular ageing
Working out the concentration
Vesugen ships as a lyophilized powder, so nothing on this page can state a concentration: the figure you work with is the one you create when you add diluent. Put the vial mass and the volume you intend to use into the peptide reconstitution calculator and it returns mg/mL, mcg/mL and the mass sitting at each mark on a U-100 syringe.
If the protocol asks for a molar concentration, the molar concentration calculator converts between 390.39 g/mol, the mass you weigh out and the volume you dissolve it in.
Certificate of analysis
Every lot of Vesugen is released against a certificate of analysis: the batch-specific laboratory data for that lot, not a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
Purity: ≥99% by HPLC — the specification for this listing. The figure for the lot you receive is the one reported on that lot’s certificate.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about Vesugen
What is Vesugen?
Vesugen is the synthetic tripeptide Lys-Glu-Asp (KED) from the Khavinson short-peptide bioregulator family, associated in that literature with vascular tissue. It is supplied as a lyophilized research chemical for laboratory investigation only.
What purity is it supplied at?
Every lot is HPLC tested against a ≥99% purity specification, and a lot-matched certificate of analysis is available. The COA lists the batch number, purity result, identity confirmation, and physical description of the powder you receive.
How does it differ from Vilon?
Vesugen is Vilon's Lys-Glu sequence extended by one aspartate residue. That single addition changes the molecular weight, the net charge at neutral pH, and the tissue association reported in the source literature, which is why the two are often compared directly.
How should the vial be stored?
Keep the unopened lyophilized vial at −20 °C, away from light and moisture. After reconstitution, hold the solution at 2–8 °C for the planned study window, or freeze single-use aliquots if the material will be used over a longer period.
Which solvent is normally used?
Bacteriostatic or sterile water is standard for reconstituting this peptide in laboratory workflows. It dissolves readily in aqueous media; buffer choice beyond that depends on the assay and should be validated for pH and ionic strength compatibility.
