- ≥99% by HPLC
- Lot-matched certificate of analysis
- Ships next business day, tracked
Vialox (Pentapeptide-3V)
GPRPA pentapeptide for postsynaptic nicotinic-receptor model research
- FormLyophilized powder, sealed glass vial
- Mol. weight495.58 g/mol
- Research areasNicotinic acetylcholine receptor models, postsynaptic signaling and contraction-associated assays
Overview
Vialox is the common catalog name for the synthetic pentapeptide Gly-Pro-Arg-Pro-Ala, also called Pentapeptide-3V or Pentapeptide-3. Its two proline residues constrain backbone geometry, while the central arginine gives the molecule a positive charge near neutral pH. The defined peptide has formula C21H37N9O5 and molecular weight 495.58 g/mol.
Research and cosmetic-science reviews discuss Vialox as a small peptide studied in postsynaptic nicotinic acetylcholine receptor and contraction-associated models, often using curare-like antagonism as a mechanistic hypothesis. Direct evidence is limited and should not be conflated with botulinum toxin, tubocurarine or Syn-AKE, all of which are chemically and pharmacologically different.
The product is supplied as 200 mg of lyophilized GPRPA in a sealed research vial. Each lot is analyzed by HPLC and supported by a lot-matched certificate of analysis. It is not a neuromuscular drug or finished cosmetic and is intended only for controlled laboratory work.
Specifications
Identity
- CAS number
- 135679-88-8
- Molecular formula
- C21H37N9O5
- Molecular weight
- 495.58 g/mol
- Amino acid sequence
- Gly-Pro-Arg-Pro-Ala-OH (GPRPA)
- Chain length
- 5 residues
- Peptide class
- Synthetic proline-rich pentapeptide
Supply & purity
- Form
- Lyophilized powder, sealed glass vial
- Purity
- ≥99% by HPLC; lot-matched COA available
- Solubility
- Water-soluble; neutral buffered systems are commonly used
Additional detail
- Available size
- 200 mg
- Also known as
- Vialox, Pentapeptide-3V, Pentapeptide-3
- Research areas
- Nicotinic acetylcholine receptor models, postsynaptic signaling and contraction-associated assays
- Storage
- −20 °C lyophilized, protected from light and moisture
Working out the concentration
Reconstitution is where the arithmetic lives. The same vial made up with 1 mL or with 3 mL of diluent gives three-fold different numbers, which is why a reconstitution volume calculator is more use here than a fixed table: enter the vial mass and your diluent volume and read the concentration back.
If the protocol asks for a molar concentration, the molar concentration calculator converts between 495.58 g/mol, the mass you weigh out and the volume you dissolve it in.
Certificate of analysis
Every lot of Vialox (Pentapeptide-3V) is released against a certificate of analysis: the batch-specific laboratory data for that lot, not a generic document for the compound. The lot number on the certificate matches the lot number printed on the label you receive — the vial label itself, where the product is vialled — so the record and the material it describes can always be reconciled.
Purity: ≥99% by HPLC — the specification for this listing. The figure for the lot you receive is the one reported on that lot’s certificate.
No lot certificate is on display on this page at the moment. That is a publishing state and not a testing one: lots are released and documented as described above whether or not the document is posted here, and we will send what exists for the lot in stock, or for a lot already on your bench, by its number.
Certificates are available on request before you order as well as after, with no account and no charge. Request the certificate for this listing, read the testing and documentation policy in full, or see how to read a peptide COA.
Questions about Vialox (Pentapeptide-3V)
What is the sequence of Vialox?
Vialox is the five-residue peptide Gly-Pro-Arg-Pro-Ala, abbreviated GPRPA. It is also cataloged as Pentapeptide-3V or Pentapeptide-3.
Is Vialox the same as Syn-AKE?
No. Vialox is an ordinary defined pentapeptide. Syn-AKE is a modified diaminobutyroyl benzylamide supplied as a diacetate salt. Similar research positioning does not make them chemical duplicates.
Is Vialox related to botulinum toxin?
Only as a very broad comparison in contraction-associated research. Botulinum toxin is a large protease with a fundamentally different mechanism and hazard profile. Vialox is a five-residue peptide and must not be described as equivalent.
What purity documentation is available?
The peptide is released at ≥99% by reversed-phase HPLC with a lot-matched certificate of analysis. Identity confirmation should correspond to the GPRPA free-peptide mass.
How should Vialox be stored?
Keep the sealed lyophilized vial at −20 °C, dry and protected from light. Refrigerate prepared working solutions for a defined study window and use aliquots for longer schedules.
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